GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs1056667 | 1 | rs6926629 | chr6:26499903 | ZNF322A | chr6:26634612-26659963:- | -0.14 | -3.79 | 0.000169 | Educational attainment |
| THCA | cis | rs6927188 | 1 | rs6927188 | chr6:42912589 | GNMT | chr6:42928500-42931617:+ | 0.41 | 8.65 | 7.93E-17 | Diabetic kidney disease |
| THCA | cis | rs6927188 | 1 | rs6927188 | chr6:42912589 | PEX6 | chr6:42931613-42946981:- | -0.51 | -10.39 | 6.42E-23 | Diabetic kidney disease |
| THCA | cis | rs6911965 | 1 | rs6928435 | chr6:24467366 | GMNN | chr6:24775159-24786276:+ | -0.28 | -3.8 | 0.000163 | Hematological and biochemical traits |
| THCA | cis | rs6911965 | 1 | rs6928435 | chr6:24467366 | GPLD1 | chr6:24428405-24489850:- | 0.25 | 4.74 | 2.85E-6 | Hematological and biochemical traits |
| THCA | cis | rs6911965 | 1 | rs6928435 | chr6:24467366 | MRS2 | chr6:24403153-24425809:+ | 0.24 | 5.48 | 6.98E-8 | Hematological and biochemical traits |
| THCA | cis | rs7756935 | 1 | rs6928546 | chr6:46632006 | CYP39A1 | chr6:46517445-46620523:- | -0.31 | -4.83 | 1.81E-6 | Lipoprotein-associated phospholipase A2 activity and mass |
| THCA | cis | rs9362426 | 1 | rs6930076 | chr6:88088654 | C6orf162 | chr6:88032306-88052043:+ | -0.18 | -3.91 | 0.000105 | Depressive episodes in bipolar disorder |
| THCA | cis | rs9362426 | 1 | rs6930076 | chr6:88088654 | C6orf164 | chr6:88032306-88109459:+ | -0.32 | -5.91 | 6.54E-9 | Depressive episodes in bipolar disorder |
| THCA | cis | rs1056667 | 1 | rs6930120 | chr6:26555484 | BTN2A3 | chr6:26422317-26431927:+ | 0.18 | 4.3 | 2.03E-5 | Educational attainment |
| THCA | cis | rs1056667 | 1 | rs6930120 | chr6:26555484 | HCG11 | chr6:26521934-26527610:+ | -0.21 | -4.14 | 4.06E-5 | Educational attainment |
| THCA | cis | rs1056667 | 1 | rs6930120 | chr6:26555484 | HMGN4 | chr6:26538572-26547162:+ | -0.16 | -4.02 | 6.69E-5 | Educational attainment |
| THCA | cis | rs1056667 | 1 | rs6930120 | chr6:26555484 | LOC100270746 | chr6:26987146-26988085:- | -0.14 | -3.44 | 0.000623 | Educational attainment |
| THCA | cis | rs1056667 | 1 | rs6930120 | chr6:26555484 | ZNF322A | chr6:26634612-26659963:- | -0.16 | -4.55 | 6.93E-6 | Educational attainment |
| THCA | cis | rs943466 | 1 | rs6930201 | chr6:33738749 | LEMD2 | chr6:33738991-33756906:- | 0.24 | 5.05 | 6.4E-7 | Body mass index |